Ingabe uyazi mayelana nokusetshenziswa nokuguqulwa kwe-PLA evulekile-hole impahla

I-Polymer porous material i-polymer material enezimbotshana eziningi ezakhiwe yigesi ehlakazwe ku-polymer material.
Lesi sakhiwo esikhethekile esinezimbotshana sihle kakhulu ekusetshenzisweni kwezinto ezimunca umsindo, ukuhlukaniswa kanye ne-adsorption, ukukhululwa okuqhubekayo kwezidakamizwa, i-scaffold yamathambo neminye imikhakha.

Izinto zendabuko ezinama-porous, njenge-polypropylene ne-polyurethane, akulula ukucekelwa phansi futhi kuthathwe i-petroleum njengezinto zokusetshenziswa, okuzodala ukungcoliswa kwemvelo.
Ngakho-ke, abantu baqala ukufunda izinto ezivulekile zembobo ebolayo.

Ukusetshenziswa kwe-PLA open-hole material:

I-PLA open-hole material nayo inobubi obuthile, obukhawulela ukusetshenziswa kwayo emkhakheni wezinto ezinembobo evulekile, njenge:

1. I-Crisp texture, amandla aphansi aqinile kanye nokuntuleka kokunwebeka kwento enezimbobo.
2. Izinga lokuwohloka kancane.
Uma ishiywe emzimbeni isikhathi eside njengesidakamizwa, ingabangela ukuvuvukala.
3. Khipha amanzi.
Ukuhlobana okuphansi kwamaseli, uma kwenziwa amaseli amathambo okwenziwa noma ama-scaffold anzima ukunamathela nokwanda.

Ukuze kuthuthukiswe ukushiyeka kwezinto ze-PLA ezivulekile, ukuxuba, ukugcwalisa, i-copolymerization nezinye izindlela zamukelwa ukuze kuthuthukiswe izinto ezivulekile ze-PLA.
Okulandelayo kunezinhlelo ezimbalwa zokuguqula ze-PLA:

1.PLA/PCL ukuxuba ukuguqulwa
I-PCL, noma i-polycaprolactone, iphinde ibe yinto ebolayo enokuhambisana okuhle kwe-biocompatibility, ukuqina namandla aqinile.
Ukuxutshwa ne-PLA kungathuthukisa ngempumelelo amandla okuqina e-PLA.
Abacwaningi bathola ukuthi izakhiwo zingalawulwa ngokulawula isilinganiso se-PCL ne-PLA.Lapho isilinganiso sobuningi se-PLA ku-PCL singu-7:3, amandla e-tensile kanye ne-modulus yezinto zaziphakeme.
Kodwa-ke, ukuqina kuncipha ngokwanda kobubanzi be-pore.
Impahla ye-PLA/PCL ayinabo ubuthi futhi inamandla okusebenza ezicutshini zemithambo ezincane ezinobubanzi obuncane.

2.PLA/PBAT ukuguqulwa kwenhlanganisela

I-PBAT iyinto ewohlokayo, enokonakala kwe-aliphatic polyester kanye nokuqina kwe-polyester enamakha.I-brittleness ye-PLA ingathuthukiswa ngemuva kokuhlanganiswa ne-PLA.

Ucwaningo lubonisa ukuthi ngokwanda kokuqukethwe kwe-PBAT, i-porosity yezinto ezivulekile zembobo yancipha (i-porosity iphakeme kakhulu uma okuqukethwe kwe-PBAT kungu-20%), futhi ukuphakama kokuphuka kuyanda.
Kuyathakazelisa ukuthi nakuba ukungezwa kwe-PBAT kunciphisa amandla e-PLA aqinile, amandla aqinile e-PLA asakhula uma ecutshungulwa enziwe izinto ezivulekile.

3.PLA/PBS ukuxuba ukuguqulwa

I-PBS iyimpahla ebolayo, enezinto ezinhle zokusebenza, ukumelana nokushisa okuhle kakhulu, ukuguquguquka nekhono lokucubungula, futhi isondelene kakhulu nezinto ze-PP ne-ABS.
Ukuhlanganisa i-PBS ne-PLA kungathuthukisa ukuqina nokucutshungulwa kwe-PLA.
Ngokusho kocwaningo, lapho isilinganiso sobuningi se-PLA: i-PBS ingu-8: 2, umphumela ophelele wawungcono kakhulu;uma i-PBS yengezwe ngokweqile, i-porosity yezinto ezivulekile zembobo izoncishiswa.

4.PLA/ Ukuguqulwa kwengilazi ye-BIOactive (BG) yokugcwalisa

Njengento yengilazi esebenzayo, i-BG ikakhulukazi yakhiwe nge-silicon sodium calcium phosphorus oxide, engathuthukisa izakhiwo zemishini kanye ne-bioactivity ye-PLA.

Ngokukhula kokuqukethwe kwe-BG, imodyuli eqinile yento evulekile yembobo iye yanda, kodwa amandla aqinile nobude ngesikhathi sekhefu kwehlile.
Uma okuqukethwe kwe-BG kungu-10%, i-porosity ye-open-hole material iphezulu kakhulu (87.3%).
Lapho okuqukethwe kwe-BG kufinyelela ku-20%, amandla okucindezela wenhlanganisela aphakeme kakhulu.
Ngaphezu kwalokho, i-PLA/BG eyinhlanganisela ye-porous material ingafaka ungqimba lwe-apatite ye-osteoid ngaphezulu nangaphakathi kuketshezi lomzimba olulingiswayo, olungaheha ukuvuselelwa kwamathambo.Ngakho-ke, i-PLA/BG inamandla okusetshenziswa ezintweni zokuxhunyelelwa amathambo.